Factor XIIIa,from Ruminant plasma


Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. A cleavage by thrombin between residue Arg37 and Gly38 on the N-terminus of the A subunit, leads to the release of the activation peptide (MW 4000 da). In the presence of calcium the carrier subunits dissociate from the catalytic subunits, leading to a 3D change in conformation of factor XIII and hence the exposure of catalytic cysteine residue. Upon activation by thrombin, factor XIIIa acts on fibrin to form γ-glutamyl-Є-lysyl amide cross links between fibrin molecules to form an insoluble clot.

Activated factor XIII (FXIIIa) is mainly used to Raw Material of Thromboelastometer Reagent.

Physical and Chemical Properties

Origin Ruminant plasma Appearance lyophilized powder
EC No. Specific activity >80IU/mg protein
Molecular structure Shown in the right figure Concentration >2mg/ml
Molecular weight About 320 kDa Purity (SDS-PAGE) ≥ 95%


  • Reconstitute the entire contents of a vial in distilled water or buffer to obtain an appropriate solution.
  • The solution could be kept at 2 to 8 °C for about one month.
  • Wear gloves and avoid breathing vapors, mist or gas generated from this material.


This product is only used for laboratory R&D and industrial quality control.

Do NOT use it as drugs or in vivo experiments.





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