Month: April 2019

Asnail now offers chromogenic substrates (S-2222 and S-2765) for factor VIII assay. The chromogenic assay is recommended for clinical diagnosis of haemophilia, monitoring factor replacement therapies and potency assignment of recombinant factor VIII.

Coagulation factor VIII (FVIII) performs a critical role in the intrinsic blood coagulation pathway. The typical quantitative chromogenic assay for coagulation factor VIII is specified in European Pharmacopoeia, as a two-stage procedure.

In this assay, coagulation factor VIII first catalyzes the transformation of factor X into its activated form, factor Xa, which in turn catalyzes the release of pNA from the substrate (S-2222 or S-2765). The potency of coagulation factor VIII is deduced by measuring the chromophore, pNA.

Asnail now offers two chromogenic substrates for this assay.

• S-2222, Chromogenic Substrate for Factor Xa, for Coagulation Testing
• S-2765, Chromogenic Substrate for Factor Xa, for Coagulation Testing

Asnail now offers chromogenic substrates in gram grade for coagulation testing.

These large-quantity chromogenic substrates can be used in chromogenic assay kits.

• S-2222, Chromogenic Substrate for Factor Xa, for Coagulation Testing
• S-2765, Chromogenic Substrate for Factor Xa, for Coagulation Testing
• S-2238, Chromogenic Substrate for Thrombin, for Coagulation Testing

For more information, please contact us via info@asnailtech.com.

Asnail now offers a wide range of reagents used in chromogenic assays for heparin.

Chromogenic Substrates

Asnail’s chromogenic substrates including:

S-2238, Chromogenic Substrate for Thrombin

S-2222, Chromogenic Substrate for Factor Xa

S-2765, Chromogenic Substrate for Factor Xa

Coagulation Factors

Asnail’s coagulation factors including:

Activated Factor X (FXa)

Alpha-Thrombin (FIIa)

Antithrombin

Asnail provides human antithrombin for both anti-FIIa and anti-FXa assays.

Human Antithrombin

With our expertise in heparin analysis, we also offer technical support with regard to chromogenic assays for heparin and LMWHs.

For more information, please contact us.

Asnail provides heparinases for heparin analysis, particularly for determining the 1,6-anhydro derivatives in exnoxaparin sodium.

All these heparinases are native enzymes from from Flavobacterium Heparinum. Please check the following links for detailed information.

Heparinase I

Heparinase II

Heparinase III

Click here to download the heparinases catalog.

For more information, please contact Asnail.