Heparinase II, for EP Method


Asnail provides heparinase II for determining 1,6-anhydro derivatives in heparin sodium. This enzyme has proven to meet the system suitability required by the European Pharmacopoeia method.

SKU: AS00-6512-EP Category: Tags: , , ,

Description

Heparinase II (heparin lyase II) cleaves heparin and heparan sulfate.

Asnail provides heparinase II for determining 1,6-anhydro derivatives in heparin sodium. This enzyme has proven to meet the system suitability required by the European Pharmacopoeia method.

System suitability required by the European Pharmacopoeia Method:

– peak area ratio: maximum 1.15 for the peaks due to 1,6-anhydro ΔIS-IS and 1,6-anhydro ΔIS in the chromatogram obtained with reference solution (b);

– maximum 0.02 for the peaks due to ΔIS and reduced ΔIS in the chromatogram obtained with reference solution (c);

– resolution: minimum 1.5 between the peaks due to reduced ΔIA and 1,6-anhydro ΔIS in the chromatogram obtained with refer-ence solution (c);

– the content of 1,6-anhydro derivatives in heparin sodium CRS is within 1.5 percent of the assigned content.

Properties:

Origin Flavobacterium Heparinum Purity (HPLC) ≥ 99%
CAS Number 149371-12-0 Specific Activity ≥ 15 IU/mg (with heparin)
≥ 18 IU/mg (with heparan sulfate)
EC Number None Concentration 4 IU/mL
Molecular Weight 84.1 kDa Storage Temperature -20 °C

Applications:

Asnail™ heparinase II is used for determining 1,6-anhydro derivatives in heparin sodium.

Order information:

Cat. # Description Qty.
AS00-6512-EP Heparinase II, from Flavobacterium Heparinum,
for the European Pharmacopoeia Method
0.1 IU

Related Products:

Cat. # Description
AS00-2519 Heparinase I, from Flavobacterium Heparinum
AS00-6512 Heparinase II, from Flavobacterium Heparinum
AS00-8891 Heparinase III, from Flavobacterium Heparinum
AS00-2519-EP Heparinase I-EP, from Flavobacterium Heparinum
AS00-8891-EP Heparinase III-EP, from Flavobacterium Heparinum

Asnail Chinese Website:www.asnailtech.com.cn

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