Description
Batroxobin, also known as reptilase, is a snake venom produced by Bothrops atrox and Bothrops moojeni, venomous species of pit viper found east of the Andes in South America. It is a hemotoxin which acts as a serine protease closely related to thrombin, and has been the subject of many medical studies as a replacement of thrombin. Different enzymes, isolated from different species of Bothrops, have been called batroxobin, but unless stated otherwise, this article covers the batroxobin produced by B. moojeni, as this is the most studied variety.
Batroxobin is mainly used to Functional Fibrinogen of Thromboelastometer.
Physical and Chemical Properties
| Origin | Bothrops atrox venom | Appearance | Clear solution |
|---|---|---|---|
| CAS No. |
9039-61-6 |
Specific activity | >1200BU/mg protein |
| Molecular structure | None | Concentration | >0.45mg/ml |
| Molecular weight | About 33 kDa | Purity | ≥ 95% |
Applications
- Decompose fibrinogen and inhibit thrombosis.
- Induce the release of TPA, enhance the effect of TPA, promote the production of fibrinolytic enzyme, reduce α2-P1 and PAI,dissolving thrombus.
- Reduce blood viscosity, inhibit erythrocyte agglutination, sedimentation, enhance the blood vessel passing and deforming ability of erythrocyte, reduce vascular resistance and improve microcirculation.So that the thrombolytic effect quickly, ischemic site function recovery, In order to achieve treatment and prevent recurrence of the effect.
Usage
Reconstitute the entire contents of a vial in distilled water or buffer to obtain an appropriate solution.
The solution could be kept at 2 to 8 °C for about 7 days.
Wear gloves and avoid breathing vapors, mist or gas generated from this material.
Caution
Extreme caution should be used when handling this material as there is a margin of error in all tests.
This product is to be used for IN VITRO research purposes only.
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